Studiile clinice ale ingredientelor active din FirmUp! Crema pentru corp

  1. “Phytochemical Characterization and in vivo Anti-inflammatory and Wound-healing Activities of Argania spinosa (L.) Skeels Seed Oil” Hadjira Dakiche, Mustapha Khali and Houcine Boutoumi.
  2. “The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity”, Kenza Qiraouani Boucetta, Zoubida Charrouf, Hassan Aguenaou, Abdelfattah Derouiche, Yahya Bensouda.
  3. “Argan oil: Occurrence, composition and impact on human health”, Zoubida Charrouf and Dominique Guillaume.
  4. Comparative Trial of Moisturizer Containing Spent, Grain Wax, Butyrospermum parkii Extract, Argania spinosa Kernel Oil vs. 1% Hydrocortisone Cream in the Treatment of Childhood Atopic Dermatitis”, Panaya Jirabundansuk MD, Suwirakorn Ophaswongse MD, Montree Udompataikul MD.
  6. “Caffeine’s Mechanisms of Action and Its Cosmetic Use”, Herman A.P. Herman
  7. Efficacy of Slimming Cream Containing 3.5% Water-Soluble Caffeine and Xanthenes for the Treatment of Cellulite: Clinical Study and Literature Review”, Sang-Young Byun, Soon-Hyo Kwon, Su-Hak Heo, Jae-Seong Shim, Mi-Hee Du, Jung-Im Na.
  8. Harahap, D. H., Argentina, F., Kurniawati, Y., Murti, C. T., & Satrio, Y. D. (2018). Efficacy of Topical Coffee Paste to Collagen Density in Wistar Rats Incision Wound. Bioscientia Medicina : Journal of Biomedicine and Translational Research, 2(1), 12-15.
  9. Kyung Eun Lee, Shiv Bharadwaj, Umesh Yadava & Sang Gu Kang (2019) Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach, Journal of Enzyme Inhibition and Medicinal Chemistry, 34:1, 927-936, DOI: 1080/14756366.2019.1596904
  10. Seleem, M., Abulfadl, Y.S., Hoffy, al. Promising role of topical caffeine mesoporous gel in collagen resynthesis and UV protection through proline assessment. Futur J Pharm Sci 8, 27 (2022).
  11. Dewi S., Cahyono A., P. A. and Mawardi P. (2018).The Comparison of the Effects of Caffeine Topical 0.25% and 0.5% as Anti-wrinkle Therapy.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 113-117. DOI: 10.5220/0008152001130117
  12. Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, Oros-Ovalle C, Fuentes-Ahumada C, González FJ, Martínez-Ramírez JD, Moncada B. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatol Res Pract. 2011;2011:379173. doi: 10.1155/2011/379173. Epub 2011 Jul 21. PMID: 21822427; PMCID: PMC3142702.
  13. Citation: Boo,Y.C.MechanisticBasis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation. Antioxidants 2021, 10,1315. antiox10081315
  14. Shariff R, Du Y, Dutta M, Kumar S 5th, Thimmaiah S, Doraiswamy C, Kumari A, Kale V, Nair N, Zhang S, Joshi M, Santhanam U, Qiang Q, Damodaran A. Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide. Int J Cosmet Sci. 2022 Feb;44(1):103-117. doi: 10.1111/ics.12759. Epub 2022 Feb 1. PMID: 34958693; PMCID: PMC9305876.
  15. Levin J, Momin SB. How much do we really know about our favorite cosmeceutical ingredients? J Clin Aesthet Dermatol. 2010 Feb;3(2):22-41. PMID: 20725560; PMCID: PMC2921764.
  16. Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005 Jul;31(7 Pt 2):860-5; discussion 865. doi: 10.1111/j.1524-4725.2005.31732. PMID: 16029679.
  17. Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.
  18. Bains P, Kaur M, Kaur J, Sharma S. Nicotinamide: Mechanism of action and indications in dermatology. Indian J Dermatol Venereol Leprol 2018;84:234-7.
    Don Bissett, Cindy Berge, Procter & Gamble, Cincinnati, OH, United States; Peiwen Sun, Procter & Gamble, Kobe, Japan; Kukizo Miyamoto, Procter & Gamble, Cincinnati, OH, United States; DOI:
  20. Klimek-Szczykutowicz, M.; Szopa, A.; Ekiert, H.Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and CosmeticsIndustries, and Biotechnological Studies. Plants 2020, 9, 119.
  21. Guzmán,E.;Lucia,A. Essential Oils and Their Individual Components in Cosmetic Products. Cosmetics2021,8,114. https://
  22. Patrizia A d'Alessio, Marie C Béné, Chantal Menut.d-Limonene challenging anti-inflammatory strategies[J]. AIMS Molecular Science, 2022, 9(2): 46-65. doi: 3934/molsci.2022003 
  23. Bertuzzi, Gianluigi & Tirillini, Bruno & Angelini, Paola & Venanzoni, Roberto. (2013). Antioxidative Action of Citrus limonum Essential Oil on Skin. European Journal of Medicinal Plants. 3. 1-9.
  24. d'Alessio PA, Mirshahi M, Bisson JF, Bene MC. Skin repair properties of d-Limonene and perillyl alcohol in murine models. Antiinflamm Antiallergy Agents Med Chem. 2014 Mar;13(1):29-35. doi: 10.2174/18715230113126660021. PMID: 24160248.
  25. Anti-inflammatory and skin repair treatments with d-limonene, Patrizia A. d’Alessio, Chantal Menut, Jocelyne Lejay, Jean-François Bisson, and Marie C. Béné review the evidence surrounding the use of d-limonene for skin rejuvenation.
  26. Souza de Carvalho VM, Covre JL, Correia-Silva RD, Lice I, Corrêa MP, Leopoldino AM, Gil CD. Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects. J Photochem Photobiol B. 2021 Aug;221:112247. doi: 10.1016/j.jphotobiol.2021.112247. Epub 2021 Jun 19. PMID: 34175580.
  27. Da Costa, Adilson & Pereira, M. & Moisés, T. & Cordero, T. & Silva, A.R. & Amazonas, F.T.P. & Bentivoglio, F. & Pereira, Elisangela. (2011). Evaluation of quality of life improvement in melasma patients, measured by the MELASQoL following the use of a botanical combination based on Bellis perennis, Glycyrrhiza glabra e Phyllanthus emblica.. Surgical and Cosmetic Dermatology. 3. 207-212.
  28. Surendran S, Qassadi F, Surendran G, Lilley D and Heinrich M (2021) Myrcene—What Are the Potential Health Benefits of This Flavouring and Aroma Agent? Front. Nutr. 8:699666. doi: 10.3389/fnut.2021.699666
  29. Colvan, L,Fleck, T,  Vega, VL.  Global periorbital skin rejuvenation by a topical eye cream containing low molecular weight heparan sulfate (LMW-HS) and a blend of naturally derived extracts. J Cosmet Dermatol. 2019; 18: 530 538.
  30. Karakaş FP, Karakaş A, Boran Ç, Türker AU, Yalçin FN, Bilensoy E. The evaluation of topical administration of Bellis perennis fraction on circular excision wound healing in Wistar albino rats. Pharm Biol. 2012 Aug;50(8):1031-7. doi: 10.3109/13880209.2012.656200. PMID: 22775421.
  31. FORMULATION AND EVALUATION OF WOUND HEALING HERBAL GEL OF BELLIS PERENNIS FLOWER EXTRACT”, Varsha Suryavanshi, Dr. Neelesh Chaubey Dr. C.K.Tyagy, Dr. Anurag Jain, Mr. Firoz Khan.
  32. Murphy MJ, Dow AA. Natural Cosmeceutical Ingredients for the Management of Hyperpigmentation in Hispanic and Latino Women. J Clin Aesthet Dermatol. 2021 Aug;14(8):52-56. Epub 2021 Aug 1. PMID: 34840659; PMCID: PMC8570660.
  33. Morikawa T, Ninomiya K, Takamori Y, Nishida E, Yasue M, Hayakawa T, Muraoka O, Li X, Nakamura S, Yoshikawa M, Matsuda H. Oleanane-type triterpene saponins with collagen synthesis-promoting activity from the flowers of Bellis perennis. Phytochemistry. 2015 Aug;116:203-212. doi: 10.1016/j.phytochem.2015.05.011. Epub 2015 May 28. PMID: 26028520.
  34. Al-Snafi, Ali. (2015). The Pharmacological importance of Bellis perennis - A review. International Journal of Phytotherapy. 5. 63-69.
  35. Kavalcioğlu N, Açik L, Demirci F, Demirci B, Demir H, Başer KH. Biological activities of Bellis perennis volatiles and extracts. Nat Prod Commun. 2010 Jan;5(1):147-50. PMID: 20184041.