Rezultate studii clinice FIRM UP! - CREMĂ DE CORP ILUMINATOARE
Efectul de albire a pielii demonstrat și evaluat pe 20 de femei.
Dupa 28 de zile consecutive de utilizare a produsului, s-a inregistrat o scadere semnificativa a nivelului de melanina cu 18.40%.
*masurat cu Mexameter MX18 la nivelul unei coapsei (p< 0.0001)
Nivelul de hidratare a crescut cu pana la 28.86% după 28 de zile de utilizare a tratamentului cosmetic.
*măsurat pe coapse cu Corneometer CM825 (p< 0.0001)
Aplicare usoara 100%
Nu lasa urma grasa dupa aplicare 100%
Textura placuta 100%
Miros placut 100%
Reechilibreaza tonul neuniform al pielii 100%
Imbunatateste vizibil aspectul pielii 100%
Confera elasticitate pielii 100%
Imbunatateste vizibil aspectul pielii 100%
Pielea isi recapata aspectul sanatos 100%
Confera catifelare pielii 100%
Hidrateaza eficient pielea 100%
Creste luminozitatea pielii 100%
*Self-assessment - aplicare de 2 ori/zi 28 de zile
11-in-1 Skincare
Ingredients
Aqua, Helianthus Annuus Seed Oil, Bellis Perennis Flower Extract, Mangifera Indica Seed Butter, Cetearyl olivate, Sorbitan olivate, Niacinamide, Argania spinosa kernel oil, Caffeine, Glycerin, Sodium levulinate, Sodium anisate, Glycoproteins, Salix Nigra Bark Extract, Potassium Sorbate, Polyglyceryl-3 Beewax, Dehydroacetic acid, Benzyl alcohol, Citrus Limon Peel Oil, Cymbopogon Flexuosus Oil, Lysolecithin, Bentonite clay, Xanthan gum, Rosmarinus officinalis leaf extract, Tocopherol, Sodium phytate, Alcohol, Mica, CI 77891, Citral, Limonene, Linalool , Citronellol, Geraniol, Isoeugenol.
FirmUp! offers total transparency, giving you a clear view of the effectiveness of each ingredient. In addition, each precious element is meticulously preserved in Miron Glass bottles, which ensure optimal protection and maintain the integrity of the formulation from the first to the last use.
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Lemon Essential Oil
Lemon Essential Oil
Free of furanocoumarins to avoid allergic reactions and photosensitization. Lemon essential oil restores skin tone, helps maintain collagen in its active, non-fibrous form.
Free of furanocoumarins to avoid allergic reactions and photosensitization. Lemon essential oil restores skin tone, helps maintain collagen in its active, non-fibrous form.
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Plant Collagen
Plant Collagen
Provides suppleness and elasticity to the skin.
Provides suppleness and elasticity to the skin.
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Daisy Oil Extract
Daisy Oil Extract
Helps maintain skin tone, works to restore skin firmness, aids in revitalizing sagging and loose skin.
Helps maintain skin tone, works to restore skin firmness, aids in revitalizing sagging and loose skin.
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Mango Butter
Mango Butter
Moisturizes the skin by restoring the lipid level on the skin's surface.
Moisturizes the skin by restoring the lipid level on the skin's surface.
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Organic Argan Oil
Organic Argan Oil
Helps with epidermal regeneration, maintains skin elasticity and tone.
Helps with epidermal regeneration, maintains skin elasticity and tone.
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Caffeine
Caffeine
Lipolytic role, reduces fat accumulation in adipose tissue, strengthens peripheral microcirculation, restoring skin firmness. Acts against photoaging (clinically demonstrated, in vivo and in vitro).
Lipolytic role, reduces fat accumulation in adipose tissue, strengthens peripheral microcirculation, restoring skin firmness. Acts against photoaging (clinically demonstrated, in vivo and in vitro).
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Niacinamide
Niacinamide
Helps reduce skin pigmentation spots, restores skin radiance, stimulates collagen formation in the dermis (in vitro and in vivo).
Helps reduce skin pigmentation spots, restores skin radiance, stimulates collagen formation in the dermis (in vitro and in vivo).
Studiile clinice ale ingredientelor active din FirmUp! Crema pentru corp
- “Phytochemical Characterization and in vivo Anti-inflammatory and Wound-healing Activities of Argania spinosa (L.) Skeels Seed Oil” Hadjira Dakiche, Mustapha Khali and Houcine Boutoumi.
- “The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity”, Kenza Qiraouani Boucetta, Zoubida Charrouf, Hassan Aguenaou, Abdelfattah Derouiche, Yahya Bensouda.
- “Argan oil: Occurrence, composition and impact on human health”, Zoubida Charrouf and Dominique Guillaume.
- “Comparative Trial of Moisturizer Containing Spent, Grain Wax, Butyrospermum parkii Extract, Argania spinosa Kernel Oil vs. 1% Hydrocortisone Cream in the Treatment of Childhood Atopic Dermatitis”, Panaya Jirabundansuk MD, Suwirakorn Ophaswongse MD, Montree Udompataikul MD.
- “STUDY ON EFFECTIVENESS OF TWO COSMETIC CREAMS WITH ARGAN OIL AND THEIR SUBJECTIVE AND INSTRUMENTAL EVALUATION”, Carmen Popescu, Stefan Manea, Valentin Vlăduț, Neli Kinga Olah, Claudiu.
- “Caffeine’s Mechanisms of Action and Its Cosmetic Use”, Herman A.P. Herman
- “Efficacy of Slimming Cream Containing 3.5% Water-Soluble Caffeine and Xanthenes for the Treatment of Cellulite: Clinical Study and Literature Review”, Sang-Young Byun, Soon-Hyo Kwon, Su-Hak Heo, Jae-Seong Shim, Mi-Hee Du, Jung-Im Na.
- Harahap, D. H., Argentina, F., Kurniawati, Y., Murti, C. T., & Satrio, Y. D. (2018). Efficacy of Topical Coffee Paste to Collagen Density in Wistar Rats Incision Wound. Bioscientia Medicina : Journal of Biomedicine and Translational Research, 2(1), 12-15. https://doi.org/10.32539/bsm.v2i1.14
- Kyung Eun Lee, Shiv Bharadwaj, Umesh Yadava & Sang Gu Kang (2019) Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach, Journal of Enzyme Inhibition and Medicinal Chemistry, 34:1, 927-936, DOI: 1080/14756366.2019.1596904
- Seleem, M., Abulfadl, Y.S., Hoffy, N.et al. Promising role of topical caffeine mesoporous gel in collagen resynthesis and UV protection through proline assessment. Futur J Pharm Sci 8, 27 (2022). https://doi.org/10.1186/s43094-022-00417-5
- Dewi S., Cahyono A., P. A. and Mawardi P. (2018).The Comparison of the Effects of Caffeine Topical 0.25% and 0.5% as Anti-wrinkle Therapy.In Proceedings of the 23rd Regional Conference of Dermatology - Volume 1: RCD, ISBN 978-989-758-494-7, pages 113-117. DOI: 10.5220/0008152001130117
- Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, Oros-Ovalle C, Fuentes-Ahumada C, González FJ, Martínez-Ramírez JD, Moncada B. A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatol Res Pract. 2011;2011:379173. doi: 10.1155/2011/379173. Epub 2011 Jul 21. PMID: 21822427; PMCID: PMC3142702.
- Citation: Boo,Y.C.MechanisticBasis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation. Antioxidants 2021, 10,1315. https://doi.org/10.3390/ antiox10081315
- Shariff R, Du Y, Dutta M, Kumar S 5th, Thimmaiah S, Doraiswamy C, Kumari A, Kale V, Nair N, Zhang S, Joshi M, Santhanam U, Qiang Q, Damodaran A. Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide. Int J Cosmet Sci. 2022 Feb;44(1):103-117. doi: 10.1111/ics.12759. Epub 2022 Feb 1. PMID: 34958693; PMCID: PMC9305876.
- Levin J, Momin SB. How much do we really know about our favorite cosmeceutical ingredients? J Clin Aesthet Dermatol. 2010 Feb;3(2):22-41. PMID: 20725560; PMCID: PMC2921764.
- Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005 Jul;31(7 Pt 2):860-5; discussion 865. doi: 10.1111/j.1524-4725.2005.31732. PMID: 16029679.
- Matts, Paul & Oblong, John & Bissett, D.L.. (2002). A Review of the range of effects of niacinamide in human skin. Int Fed Soc Cosmet Chem Mag. 5. 285-289.
- Bains P, Kaur M, Kaur J, Sharma S. Nicotinamide: Mechanism of action and indications in dermatology. Indian J Dermatol Venereol Leprol 2018;84:234-7.
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TOPICAL NIACINAMIDE-CONTAINING PRODUCT REDUCES FACIAL SKIN SALLOWNESS (YELLOWING)
Don Bissett, Cindy Berge, Procter & Gamble, Cincinnati, OH, United States; Peiwen Sun, Procter & Gamble, Kobe, Japan; Kukizo Miyamoto, Procter & Gamble, Cincinnati, OH, United States; DOI: https://doi.org/10.1016/j.jaad.2004.10.144 - Klimek-Szczykutowicz, M.; Szopa, A.; Ekiert, H.Citrus limon (Lemon) Phenomenon—A Review of the Chemistry, Pharmacological Properties, Applications in the Modern Pharmaceutical, Food, and CosmeticsIndustries, and Biotechnological Studies. Plants 2020, 9, 119. https://doi.org/10.3390/plants9010119
- Guzmán,E.;Lucia,A. Essential Oils and Their Individual Components in Cosmetic Products. Cosmetics2021,8,114. https:// doi.org/10.3390/cosmetics8040114
- Patrizia A d'Alessio, Marie C Béné, Chantal Menut.d-Limonene challenging anti-inflammatory strategies[J]. AIMS Molecular Science, 2022, 9(2): 46-65. doi: 3934/molsci.2022003
- Bertuzzi, Gianluigi & Tirillini, Bruno & Angelini, Paola & Venanzoni, Roberto. (2013). Antioxidative Action of Citrus limonum Essential Oil on Skin. European Journal of Medicinal Plants. 3. 1-9.
- d'Alessio PA, Mirshahi M, Bisson JF, Bene MC. Skin repair properties of d-Limonene and perillyl alcohol in murine models. Antiinflamm Antiallergy Agents Med Chem. 2014 Mar;13(1):29-35. doi: 10.2174/18715230113126660021. PMID: 24160248.
- Anti-inflammatory and skin repair treatments with d-limonene, Patrizia A. d’Alessio, Chantal Menut, Jocelyne Lejay, Jean-François Bisson, and Marie C. Béné review the evidence surrounding the use of d-limonene for skin rejuvenation. https://www.aisa-tx.com/wp-content/uploads/2021/03/2015_PRIME_d_lim_Skin.pdf
- Souza de Carvalho VM, Covre JL, Correia-Silva RD, Lice I, Corrêa MP, Leopoldino AM, Gil CD. Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects. J Photochem Photobiol B. 2021 Aug;221:112247. doi: 10.1016/j.jphotobiol.2021.112247. Epub 2021 Jun 19. PMID: 34175580.
- Da Costa, Adilson & Pereira, M. & Moisés, T. & Cordero, T. & Silva, A.R. & Amazonas, F.T.P. & Bentivoglio, F. & Pereira, Elisangela. (2011). Evaluation of quality of life improvement in melasma patients, measured by the MELASQoL following the use of a botanical combination based on Bellis perennis, Glycyrrhiza glabra e Phyllanthus emblica.. Surgical and Cosmetic Dermatology. 3. 207-212.
- Surendran S, Qassadi F, Surendran G, Lilley D and Heinrich M (2021) Myrcene—What Are the Potential Health Benefits of This Flavouring and Aroma Agent? Front. Nutr. 8:699666. doi: 10.3389/fnut.2021.699666
- Colvan, L,Fleck, T, Vega, VL. Global periorbital skin rejuvenation by a topical eye cream containing low molecular weight heparan sulfate (LMW-HS) and a blend of naturally derived extracts. J Cosmet Dermatol. 2019; 18: 530– 538. https://doi.org/10.1111/jocd.12857
- Karakaş FP, Karakaş A, Boran Ç, Türker AU, Yalçin FN, Bilensoy E. The evaluation of topical administration of Bellis perennis fraction on circular excision wound healing in Wistar albino rats. Pharm Biol. 2012 Aug;50(8):1031-7. doi: 10.3109/13880209.2012.656200. PMID: 22775421.
- “FORMULATION AND EVALUATION OF WOUND HEALING HERBAL GEL OF BELLIS PERENNIS FLOWER EXTRACT”, Varsha Suryavanshi, Dr. Neelesh Chaubey Dr. C.K.Tyagy, Dr. Anurag Jain, Mr. Firoz Khan.
- Murphy MJ, Dow AA. Natural Cosmeceutical Ingredients for the Management of Hyperpigmentation in Hispanic and Latino Women. J Clin Aesthet Dermatol. 2021 Aug;14(8):52-56. Epub 2021 Aug 1. PMID: 34840659; PMCID: PMC8570660.
- Morikawa T, Ninomiya K, Takamori Y, Nishida E, Yasue M, Hayakawa T, Muraoka O, Li X, Nakamura S, Yoshikawa M, Matsuda H. Oleanane-type triterpene saponins with collagen synthesis-promoting activity from the flowers of Bellis perennis. Phytochemistry. 2015 Aug;116:203-212. doi: 10.1016/j.phytochem.2015.05.011. Epub 2015 May 28. PMID: 26028520.
- Al-Snafi, Ali. (2015). The Pharmacological importance of Bellis perennis - A review. International Journal of Phytotherapy. 5. 63-69.
- Kavalcioğlu N, Açik L, Demirci F, Demirci B, Demir H, Başer KH. Biological activities of Bellis perennis volatiles and extracts. Nat Prod Commun. 2010 Jan;5(1):147-50. PMID: 20184041.
How do you incorporate it into your beauty ritual?